The 2nd edition of My Pals are Here International Science offers a focus on awareness, collaboration, and critical and inventive thinking using an inquiry-based approach. The program is for grades 1-6 and based on the principles of engagement, exploration, explanation, elaboration, and evaluation.

There is now one Textbook, Activity Book, and Teacher's Guide per grade (as compared to the A and B books in the first edition).

In the Textbook, each unit begins with an opener designed to introduce students to the topic of study through a relatable application and questions to consider. Each unit ends with summaries, self-test questions, a science glossary specific to that unit and a “Science Today” reading that introduces current scientific developments related to that unit concept.